I’ve got a 80e swap and 3.90s.

 

nobody's really point-blank said it yet, but all these variables you've mentioned have a huge impact on each other, and you eventually have to decide on some things to better-inform your decisions on others. how you use the truck also plays a big part in it (e.g., you can have a nasty sounding chop on your tow rig, but it won't pull a trailer for crap).

right now, you seem to have at least decided on 35"s. that says you ain't looking for neck-snapping acceleration or record track times, and lower-rpm + mid-range power would be optimal (works for offroading... and mall crawling, if that's more your thing). those bigger, heavier tires will prefer the deeper gears (larger ratio number)... but your engine size, transmission, converter, and cam choices will affect the optimal diff ratio because that sets what RPM you're turning at different speeds.

the 5.3 should do just fine, but a 6.0's gonna make more hp & torque all around (at about 2-3x the price of a 5.3, if you ain't already got a motor). when looking at cams, forget all that "stage" nomenclature bullcrap - look at the actual profiles (duration, lift, etc), and have a chat with the dudes who spec them for a living like Texas Speed, Brian Tooley, Pat G, Summit, etc. off-hand, the ones suggested above in the low-mid 200°s & .500-.600ish lift would work great. once you know where that cam makes its power (longer duration generically moves higher in RPM) & you determine which transmission you're using (because the 4L60 & 4L80 have drastically different ratios), you can pair up the right torque converter & differential ratios to keep you in your powerband RPMs as you're driving.

hopefully i didn't convolute too much here.

 

4.88 gears with 35"s are perfect.
I run 4.56s in my wife's lifted Tahoe on 35"s with a cammed L33 and I wish it had 4.88s but it already had the gears when I got it.
as for a cam I had really good luck with a 223-226 604-610 110+4 in a L33, that was with 5.38 gears and 37" boggers along with a 3600 comverter. It was alot of fun for such a large truck. I also ran that setup with a built 4l65e and also a 4l80e, both had the same converter specs. I liked it alot better with the 80e.
even in a 6L that cam would work well.
I have had so many setups being lifted that I can tell you what works and what doesn't.
lol

 

Thanks for the info guys, its a huge help. Here's what I'm thinking for the cam/gearing/tc setup. 6.0 LQ4/LQ9, 4.88 gearing?, 35s, TSP 224/228 .600 112 lsa, springs, pushrods. I'm leaning towards this cam setup because a buddy of mine has it on his 6.0 and it sounds and performs great. I also spoke with TSP and they agreed this setup would work, however I wanted to run it by you all before I order the parts. Do you think this is a solid setup for my truck? Keep in mind I don't need it to be the most powerful, craziest engine build. Additionally, they recommended a 2800 to 3200 stall converter. Is there one in particular you all could recommend for this setup? Thanks in advance

 

Circle D will get you dialed on a stall for whatever combo you go with.