By changing certain cam parameters, it's possible to bleed off cylinder pressure on the bottom end, decreasing fuel octane sensitivity, even though its static compression ratio remains unchanged. The actual cylinder pressure an engine sees is often referred to as dynamic compression, because (unlike the static built-in compression ratio) it changes dynamically according to camshaft variations. The most important of these variations is the intake closing point, because it extends beyond BDC into the compression stroke. Closing the intake later aids top-end power at the expense of low-end torque. Down low, where the engine is most likely to detonate, the late intake closure bleeds off cylinder pressure, effectively dropping the dynamic compression ratio.

Changing the ICL changes the DCR. Retarding the cam delays intake closing and decreases the DCR. Advancing the cam causes the intake valve to close earlier (while the pistons is lower in the cylinder, increasing the sweep volume) which increases the DCR. This can be used to manipulate the DCR as well as moving the torque peak up or down the rpm range.
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A good approach when building an engine is to determine the duration and LSA needed for the desired RPM range. Once this is know, manipulate the chamber size and piston valve reliefs (and sometimes the cam advance) to provide a DCR around 8.2:1. Now that the correct piston volume and chamber size is know, enter the actual crankshaft stroke in your CR calculator to see what static CR to build to. Often the needed SCR is higher that you would expect. Note: The quench distance (piston/head clearance) should always be set between .035" and .045" with the lower limit giving the best performance and detonation resistance.

Alternatively, with the SCR known, manipulate the cam specs until a desirable DCR is found. When the best intake closing time is derived, look for a cam with that intake closing timing, that provides the other attributes desired (LSA and duration). Often times the best cam is smaller than one might expect. Sometimes a CR change is needed to run a cam with the desired attributes.